![]() Other advantages include measurements of both highly concentrated and highly dilute samples, and the ability to determine Zeta Potential, molecular weight and concentration, which is built into many analyzers. It is a technique suited to the analysis and characterization of nanoparticles. While Laser Diffraction (LD) often reaches its limits for particles smaller than 100 nm due to the weak signal and the low angular variance in scattering signal, this is where the strength of dynamic light scattering lies. The light scattered by particles contains information on the diffusion speed and thus on the size distribution.ĭynamic light scattering enables the analysis of particles in a size range from 0.3 nm to 10000 nm. It is based on the Brownian motion of particles - this states that smaller particles move faster, while larger ones move slower in a liquid. Please follow the link to our light scattering theory page to learn more about dynamic and static light scattering theory.Dynamic Light Scattering (DLS) is an established and precise measurement technique for characterizing particle sizes in suspensions and emulsions. Owing to the technique’s high sensitivity towards large species, even small impurities caused by aggregation can be detected Owing to its large measurement range (0.5 nm – 1 µm) DLS closes the gap between the range of small soluble aggregates that are detected via size exclusion chromatography (SEC) and particles analyzed by methods such as light obscuration (LO) or micro flow imaging (MFI). ZentriForce Pharma offers DLS services under BSL 1 and 2.ĭynamic light scattering is known as a fast and sensitive screening method for aggregate / particle detection and therefore widely used within biopharmaceutical development. We routinely conduct biosimilarity and gene therapy studies and are furthermore experienced in the development of dynamic light scattering (DLS) methods for a large variety of samples. Zentriforce Pharma is a contract research organization that specializes in analytical services with a focus on hydrodynamic methods. Asymmetrical Flow Field-Flow Fractionation (AF4) Theory.Sedimentation Equilibrium Analytical Ultracentrifugation (SE-AUC).Sedimentation Velocity Analytical Ultracentrifugation (SV-AUC) Data Evaluation Approaches.Sedimentation Velocity Analytical Ultracentrifugation (SV-AUC).DLS Services for the Development of other Gene Therapy APIs.AF4 Services for the Development of other Gene Therapy APIs.SV-AUC Services for the Development of other Gene Therapy APIs.SEC-MALLS Services for Peptide Development.SV-AUC Services for Peptide Development.SEC-MALLS Services for Biopharmaceutical Development.DLS Services for Biopharmaceutical Development.AF4 Services for Biopharmaceutical Development.SV-AUC Services for Biopharmaceutical Development.SEC-MALLS Services for Biosimilarity Studies.SV-AUC Services for Biosimilarity Studies.Dynamic Light Scattering (DLS) Services. ![]() Differential Scanning Calorimetry (μ-DSC) Services.Size Exclusion Chromatography (SEC-MALLS) Services.Asymmetrical Flow Field-Flow Fractionation (AF4) Services.Sedimentation Velocity Analytical Ultracentrifugation (SV-AUC) Services. ![]()
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